Disordered C-terminal domain drives spatiotemporal confinement of RNAPII to enhance search for chromatin targets

charts and data from the Wu lab paper in Nature

The Wu lab employed single-molecule tracking and spatiotemporal mapping in live yeast to demonstrate the necessity of the CTD in restricting RNAPII diffusion within a subnuclear area enriched with active genes in a recent study.

Numerous members of the Wu lab recently published an article on March 28, 2024 that can be found here. The article was published in Nature.