Research interest:

Effect of dietary nutrients on metabolic regulatory mechanisms, with particular emphasis on the role of proteins and amino acids in the development of behavioral and metabolic diseases.

Education:

Ph.D. in Pharmacology (2005), University of Naples ‘Federico II’, Italy.

B.Sc. Pharmaceutical Biotechnology (2001), University of Naples ‘Federico II’, Italy.

Selected publications:

Coppola A, Wenner B, Stevens R, Slotkin T, Levin E, Newgard C. Branched-chain amino acids alter neurobehavioral function in rats. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E405-13.

Wallingford N, Perroud B, Gao Q, Coppola A, Gyengesi E, Liu Z-W, Gao X-B, Diament A, Haus KA, Shariat-Madar Z, Mahdi F, Wardlaw SL, Schmaier AH, Warden CH, and Diano S. Prolylcarboxypeptidase regulates food intake by inactivating α-MSH in rodents. JCI. 2009 Aug;119(8):2291-303.

Andrews ZB, Liu Z-W, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp MH, Shanabrough M, Cline G, Shulman GI, Coppola A,Gao X-B, Horvath ML & Diano S. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature. 2008 Aug; 454: 846-851.

Coppola A and Diano S. Hormonal regulation of the arcuate nucleus melanocortin system. Front. Biosci. 2007 May 1;12:3519-30.

Coppola A, Liu ZW, Andrews ZB, Roy MC, Pinto S, Friedman JM, Ricquier D, Richard D, Gao XB, Horvath TL and Diano S. A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metabolism. 2007 Jan; 5(1): 21-33.

Mattace Raso G, Esposito E, Iacono A, Pacilio M, Coppola A, Bianco G, Diano S, Di Carlo R and Meli R. Leptin induces nitric oxide synthase type II in C6 glioma cells Role for nuclear factor-kappaB in hormone effect. Neurosci. Lett. 2006 Mar 27;396(2):121-6. Epub 2005 Dec 15.

Coppola A, Huges J, Esposito E, Schiavo L, Meli R, Sabrina D. Suppression of hypothalamic deiodinase type II activity blunts TRH mRNA decline during fasting. FEBS Letters. 2005 Aug 29; 579(21):4654-8.

Esposito E, Iacono A, Raso GM, Pacilio M, Coppola A, DI Carlo R, Meli R. Raloxifene, a Selective Estrogen Receptor Modulator, Reduces Carrageenan-induced Acute Inflammation in Normal and Ovariectomized Rats.  Endocrinology. 2005 Aug; 146(8):3301-8.

Coppola A, Meli R, Diano S. Inverse shift in circulating corticosterone and leptin levels elevates hypothalamic deiodinase type 2 in fasted rats. Endocrinology. 2005 Jun; 146(6):2827-33.

Meli R, Pacilio M, Mattace Raso G, Esposito E, Coppola A, Nasti A, Di Carlo C, Nappi C, Di Carlo R. Estrogen and raloxifene modulate leptin and its receptor in adipose tissue from ovariectomized rats. Endocrinology. 2004 Jul; 145(7):3115-21.

Mattace Raso G, Pacilio M, Esposito E, Coppola A, Di Carlo R, Meli R. Leptin induces and modulates the expression of inducible nitric oxide synthase and cyclooxygenase-2 in macrophages. Br. J. Pharmacol. 2002; 137:799-804.