Nichole is an Assistant Professor in the Department of Biology. Prior to arriving at JHU, Nichole was an Assistant Professor in the Department of Molecular and Cell Biology and the Institute for Systems Genomics at the University of Connecticut. From 2013-2015, Nichole was an Associate Research Scientist at the Molecular, Cellular & Developmental Biology Department at Yale University. Nichole received her PhD from the University of Wisconsin-Madison with Ken Raffa (Entomology) and Jo Handelsman (Microbiology) and did her postdoctoral research in the lab of Bruno Lemaitre at the EPFL in Lausanne, Switzerland. Her research has focused on characterization of the gut microbiota of insect hosts and study of their impacts on host physiology and susceptibility to disease.

The goal of the Broderick Laboratory is to address fundamental questions related to animal biology by understanding the mechanisms that underlie animal-microbiome interactions. We use Drosophila melanogaster and its associated microbiota to study the impacts of beneficial and pathogenic bacteria on host development, physiology, and health using a variety of molecular, genetic, and genomic approaches.

Animals are in constant association with diverse and abundant microbial communities, collectively referred to as the microbiome. These interactions have important roles in animal development and physiology. Research in our lab seeks to address questions such as: How does the microbiome establish and maintain itself? What are the host and microbiota factors that mediate their interactions? How stable are these microbiome-dependent effects in response to perturbation by pathogens and time? Understanding the molecular basis of these interactions will inform our understanding of the evolution of host-microbe associations and define mechanisms that promote animal health.

Link to additional research details. https://brodericklab.com/research.php

For additional publications see the Broderick Lab website.

2020

• Lesperance DNA, Broderick NA. Meta-analysis of Diets Used in Microbiome Research and Introduction of the Dietary Composition Calculator (DDCC). G3 (Bethesda) 2020;
  PMID: 32371452
• Lesperance DN, Broderick NA. Microbiomes as modulators of Drosophila melanogaster homeostasis and disease. Curr Opin Insect Sci 2020; 39:84-90
  PMID: 32339931

2019

• Lozano GL, Park HB, Bravo JI, Armstrong EA, Denu JM, Stabb EV, Broderick NA, Crawford JM, Handelsman J. Bacterial Analogs of Plant Tetrahydropyridine Alkaloids Mediate Microbial Interactions in a Rhizosphere Model System. Appl. Environ. Microbiol. 2019; 85(10)
  PMID: 30877115
• Lozano GL, Bravo JI, Garavito Diago MF, Park HB, Hurley A, Peterson SB, Stabb EV, Crawford JM, Broderick NA, Handelsman J. Introducing THOR, a Model Microbiome for Genetic Dissection of Community Behavior. mBio 2019; 10(2)
  PMID: 30837345
• Sivakumar R, Ranjani J, Vishnu US, Jayashree S, Lozano GL, Miles J, Broderick NA, Guan C, Gunasekaran P, Handelsman J, Rajendhran J. Evaluation of INSeq To Identify Genes Essential for PGPR2 Corn Root Colonization. G3 (Bethesda) 2019; 9(3):651-661
  PMID: 30705119
• Broderick NA, Casadevall A. Gender inequalities among authors who contributed equally. Elife 2019; 8
  PMID: 30698140

2018

• Mandel MJ, Broderick NA, Martens EC, Guillemin K. Reports from a Healthy Community: The 7th Conference on Beneficial Microbes. Appl. Environ. Microbiol. 2018;
  PMID: 30578257

2017

• Benoit JB, Vigneron A, Broderick NA, Wu Y, Sun JS, Carlson JR, Aksoy S, Weiss BL. Symbiont-induced odorant binding proteins mediate insect host hematopoiesis. Elife 2017; 6
  PMID: 28079523
• Benoit JB, Vigneron A, Broderick NA, Wu Y, Sun JS, Carlson JR, Aksoy S, Weiss BL. Symbiont-induced odorant binding proteins mediate insect host hematopoiesis eLife 2017; 6(19535)
  DOI: 10.7554/eLife.19535
• Fischer CN, Trautman EP, Crawford JM, Stabb EV, Handelsman J, Broderick NA. Metabolite exchange between microbiome members produces compounds that influence behavior. Elife 2017; 6
  PMID: 28068220
• Fischer CN, Trautman EP, Crawford JM, Stabb EV, Handelsman J, Broderick NA. Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior eLife 2017; 6(18855)
  DOI: 10.7554/eLife.18855 

2016

• Broderick NA. More wrinkles to Bt susceptibility. Virulence 2016; 7(8):853-855
  PMID: 27715450
• Broderick NA. More wrinkles to Bt susceptibility Virulence 2016; 7(8):853-855
  DOI: 10.1080/21505594.2016.1244596
• Stulberg ER, Lozano GL, Morin JB, Park H, Baraban EG, Mlot C, Heffelfinger C, Phillips GM, Rush JS, Phillips AJ, Broderick NA, Thomas MG, Stabb EV, Handelsman J. Genomic and Secondary Metabolite Analyses of Streptomyces sp. 2AW Provide Insight into the Evolution of the Cycloheximide Pathway. Front Microbiol 2016; 7:573
  PMID: 27199910
• Broderick NA. Friend, foe or food? Recognition and the role of antimicrobial peptides in gut immunity and Drosophila-microbe interactions. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2016; 371(1695)
  PMID: 27160597 
• Stulberg E, Lozano GL, Morin JB, Park H, Baraban EG, Mlot C, Heffelfinger C, Phillips GM, Rush JS, Phillips AJ, Broderick NA, Thomas MG, Stabb EV, Handelsman J. Genomic and secondary metabolite analyses of Streptomyces sp. 2AW provideinsight into the evolution of the cycloheximide pathway. Front Microbiol 2016; 7(573)
  PMID: 27199910 

2015

• Broderick NA. A common origin for immunity and digestion. Front Immunol 2015; 6:72
  PMID: 25745424
• Holt JF, Kiedrowski MR, Frank KL, Du J, Guan C, Broderick NA, Dunny GM, Handelsman J. Enterococcus faecalis 6-phosphogluconolactonase is required for both commensal and pathogenic interactions with Manduca sexta. Infect. Immun. 2015; 83(1):396-404
  PMID: 25385794

2014

• Udikovic-Kolic N, Wichmann F, Broderick NA, Handelsman J. Bloom of resident antibiotic-resistant bacteria in soil following manure fertilization. Proc. Natl. Acad. Sci. U.S.A. 2014; 111(42):15202-7
  PMID: 25288759 
• Broderick NA, Buchon N, Lemaitre B. Microbiota-induced changes in drosophila melanogaster host gene expression and gut morphology. MBio 2014; 5(3):e01117-14
  PMID: 24865556

2013

• Buchon N, Broderick NA, Lemaitre B. Gut homeostasis in a microbial world: insights from Drosophila melanogaster. Nat. Rev. Microbiol. 2013; 11(9):615-26
  PMID: 23893105 
• Gendrin M, Zaidman-Rémy A, Broderick NA, Paredes J, Poidevin M, Roussel A, Lemaitre B. Functional analysis of PGRP-LA in Drosophila immunity. PLoS ONE 2013; 8(7):e69742
  PMID: 23922788 

2012

• Broderick NA, Lemaitre B. Gut-associated microbes of Drosophila melanogaster. Gut Microbes 2012; 3(4):307-21
  PMID: 22572876

2010

• Buchon N, Broderick NA, Kuraishi T, Lemaitre B. Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol. 2010; 8:152
  PMID: 21176204 
• Broderick NA, Vasquez E, Handelsman J, Raffa KF. Effect of clonal variation among hybrid poplars on susceptibility of gypsy moth (Lepidoptera: Lymantriidae) to Bacillus thuringiensis subsp. kurstaki. J. Econ. Entomol. 2010; 103(3):718-25
  PMID: 20568617 
• Broderick NA, Raffa KF, Handelsman J. Chemical modulators of the innate immune response alter gypsy moth larval susceptibility to Bacillus thuringiensis. BMC Microbiol. 2010; 10:129
  PMID: 20423490 

2009

• Buchon N, Broderick NA, Chakrabarti S, Lemaitre B. Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev. 2009; 23(19):2333-44
  PMID: 19797770 
• Broderick NA, Robinson CJ, McMahon MD, Holt J, Handelsman J, Raffa KF. Contributions of gut bacteria to Bacillus thuringiensis-induced mortality vary across a range of Lepidoptera. BMC Biol. 2009; 7:11
  PMID: 19261175
• Allen HK, Cloud-Hansen KA, Wolinski JM, Guan C, Greene S, Lu S, Boeyink M, Broderick NA, Raffa KF, Handelsman J. Resident microbiota of the gypsy moth midgut harbors antibiotic resistance determinants. DNA Cell Biol. 2009; 28(3):109-17
  PMID: 19206998 
• Buchon N, Broderick NA, Poidevin M, Pradervand S, Lemaitre B. Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. Cell Host Microbe 2009; 5(2):200-11
  PMID: 19218090 
• Broderick NA, Welchman DP, Lemaitre B. Recognition and response to microbial infection of Drosophila. Insect Infection and Immunity: evolution, ecology, and mechanisms. 2009; Oxford University Press. S. Reynolds and J. Rolff (eds.)
  DOI: 10.1093/acprof:oso/9780199551354.001.0001

2006

• Broderick NA, Raffa KF, Handelsman J. Midgut bacteria required for Bacillus thuringiensis insecticidal activity. Proc. Natl. Acad. Sci. U.S.A. 2006; 103(41):15196-9
  PMID: 17005725 

2005

• Lucas D, Broderick N, Lehrer R, Bohanan R. Making the grounds of scientific inquiry visible in the classroom. Science Scope 2005; 29(3):39-42

2004

• Broderick NA, Raffa KF, Goodman RM, Handelsman J. Census of the bacterial community of the gypsy moth larval midgut by using culturing and culture-independent methods. Appl. Environ. Microbiol. 2004; 70(1):293-300
  PMID: 14711655 

2003

• Broderick NA, Goodman RM, Handelsman J, Raffa KF. Effect of host diet and insect source on synergy of gypsy moth (Lepidoptera: Lymantriidae) mortality to Bacillus thuringiensis subsp. kurstaki by zwittermicin A. Environ Entomol 2003; 32(2):387-391 

2000

• Broderick NA, Goodman RM, Raffa KF, Handelsman J. Synergy between zwittermicin A and Bacillus thuringiensis subsp. kurstaki against gypsy moth (Lepidoptera: Lymantriidae). Environ Entomol 2000; 29(1):101-107
  DOI: 10.1603/0046-225X-29.1.101 

Graduate Students

Alexander Barron

Madison Condon

Taylar Mouton

Benjamin Soto

Rose Dziedzic

Danielle Lesperance

Staff

Marika David