Nichole is an Assistant Professor in the Department of Biology. Prior to arriving at JHU, Nichole was an Assistant Professor in the Department of Molecular and Cell Biology and the Institute for Systems Genomics at the University of Connecticut. From 2013-2015, Nichole was an Associate Research Scientist at the Molecular, Cellular & Developmental Biology Department at Yale University. Nichole received her PhD from the University of Wisconsin-Madison with Ken Raffa (Entomology) and Jo Handelsman (Microbiology) and did her postdoctoral research in the lab of Bruno Lemaitre at the EPFL in Lausanne, Switzerland. Her research has focused on characterization of the gut microbiota of insect hosts and study of their impacts on host physiology and susceptibility to disease.
The goal of the Broderick Laboratory is to address fundamental questions related to animal biology by understanding the mechanisms that underlie animal-microbiome interactions. We use Drosophila melanogaster and its associated microbiota to study the impacts of beneficial and pathogenic bacteria on host development, physiology, and health using a variety of molecular, genetic, and genomic approaches.
Animals are in constant association with diverse and abundant microbial communities, collectively referred to as the microbiome. These interactions have important roles in animal development and physiology. Research in our lab seeks to address questions such as: How does the microbiome establish and maintain itself? What are the host and microbiota factors that mediate their interactions? How stable are these microbiome-dependent effects in response to perturbation by pathogens and time? Understanding the molecular basis of these interactions will inform our understanding of the evolution of host-microbe associations and define mechanisms that promote animal health.
Link to additional research details. https://brodericklab.com/research.php
2020
- Lesperance DNA, Broderick NA. Meta-analysis of Diets Used in Microbiome Research and Introduction of the Dietary Composition Calculator (DDCC). G3 (Bethesda) 2020;
PMID: 32371452
- Lesperance DN, Broderick NA. Microbiomes as modulators of Drosophila melanogaster homeostasis and disease. Curr Opin Insect Sci 2020; 39:84-90
PMID: 32339931
2019
- Lozano GL, Park HB, Bravo JI, Armstrong EA, Denu JM, Stabb EV, Broderick NA, Crawford JM, Handelsman J. Bacterial Analogs of Plant Tetrahydropyridine Alkaloids Mediate Microbial Interactions in a Rhizosphere Model System. Appl. Environ. Microbiol. 2019; 85(10)
PMID: 30877115
- Lozano GL, Bravo JI, Garavito Diago MF, Park HB, Hurley A, Peterson SB, Stabb EV, Crawford JM, Broderick NA, Handelsman J. Introducing THOR, a Model Microbiome for Genetic Dissection of Community Behavior. mBio 2019; 10(2)
PMID: 30837345
- Sivakumar R, Ranjani J, Vishnu US, Jayashree S, Lozano GL, Miles J, Broderick NA, Guan C, Gunasekaran P, Handelsman J, Rajendhran J. Evaluation of INSeq To Identify Genes Essential for PGPR2 Corn Root Colonization. G3 (Bethesda) 2019; 9(3):651-661
PMID: 30705119
- Broderick NA, Casadevall A. Gender inequalities among authors who contributed equally. Elife 2019; 8
PMID: 30698140
2018
2017
- Benoit JB, Vigneron A, Broderick NA, Wu Y, Sun JS, Carlson JR, Aksoy S, Weiss BL. Symbiont-induced odorant binding proteins mediate insect host hematopoiesis. Elife 2017; 6
PMID: 28079523
- Benoit JB, Vigneron A, Broderick NA, Wu Y, Sun JS, Carlson JR, Aksoy S, Weiss BL. Symbiont-induced odorant binding proteins mediate insect host hematopoiesis eLife 2017; 6(19535)
DOI: 10.7554/eLife.19535
- Fischer CN, Trautman EP, Crawford JM, Stabb EV, Handelsman J, Broderick NA. Metabolite exchange between microbiome members produces compounds that influence behavior. Elife 2017; 6
PMID: 28068220
- Fischer CN, Trautman EP, Crawford JM, Stabb EV, Handelsman J, Broderick NA. Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior eLife 2017; 6(18855)
DOI: 10.7554/eLife.18855
2016
- Broderick NA. More wrinkles to Bt susceptibility. Virulence 2016; 7(8):853-855
PMID: 27715450
- Broderick NA. More wrinkles to Bt susceptibility Virulence 2016; 7(8):853-855
DOI: 10.1080/21505594.2016.1244596
- Stulberg ER, Lozano GL, Morin JB, Park H, Baraban EG, Mlot C, Heffelfinger C, Phillips GM, Rush JS, Phillips AJ, Broderick NA, Thomas MG, Stabb EV, Handelsman J. Genomic and Secondary Metabolite Analyses of Streptomyces sp. 2AW Provide Insight into the Evolution of the Cycloheximide Pathway. Front Microbiol 2016; 7:573
PMID: 27199910
- Broderick NA. Friend, foe or food? Recognition and the role of antimicrobial peptides in gut immunity and Drosophila-microbe interactions. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2016; 371(1695)
PMID: 27160597
- Stulberg E, Lozano GL, Morin JB, Park H, Baraban EG, Mlot C, Heffelfinger C, Phillips GM, Rush JS, Phillips AJ, Broderick NA, Thomas MG, Stabb EV, Handelsman J. Genomic and secondary metabolite analyses of Streptomyces sp. 2AW provideinsight into the evolution of the cycloheximide pathway. Front Microbiol 2016; 7(573)
PMID: 27199910
2015
2014
2013
2012
- Broderick NA, Lemaitre B. Gut-associated microbes of Drosophila melanogaster. Gut Microbes 2012; 3(4):307-21
PMID: 22572876
2010
2009
- Buchon N, Broderick NA, Chakrabarti S, Lemaitre B. Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. Genes Dev. 2009; 23(19):2333-44
PMID: 19797770
- Broderick NA, Robinson CJ, McMahon MD, Holt J, Handelsman J, Raffa KF. Contributions of gut bacteria to Bacillus thuringiensis-induced mortality vary across a range of Lepidoptera. BMC Biol. 2009; 7:11
PMID: 19261175
- Allen HK, Cloud-Hansen KA, Wolinski JM, Guan C, Greene S, Lu S, Boeyink M, Broderick NA, Raffa KF, Handelsman J. Resident microbiota of the gypsy moth midgut harbors antibiotic resistance determinants. DNA Cell Biol. 2009; 28(3):109-17
PMID: 19206998
- Buchon N, Broderick NA, Poidevin M, Pradervand S, Lemaitre B. Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. Cell Host Microbe 2009; 5(2):200-11
PMID: 19218090
- Broderick NA, Welchman DP, Lemaitre B. Recognition and response to microbial infection of Drosophila. Insect Infection and Immunity: evolution, ecology, and mechanisms. 2009; Oxford University Press. S. Reynolds and J. Rolff (eds.)
DOI: 10.1093/acprof:oso/9780199551354.001.0001
2006
2005
- Lucas D, Broderick N, Lehrer R, Bohanan R. Making the grounds of scientific inquiry visible in the classroom. Science Scope 2005; 29(3):39-42
2004
2003
- Broderick NA, Goodman RM, Handelsman J, Raffa KF. Effect of host diet and insect source on synergy of gypsy moth (Lepidoptera: Lymantriidae) mortality to Bacillus thuringiensis subsp. kurstaki by zwittermicin A. Environ Entomol 2003; 32(2):387-391
2000
