Nichole Broderick

Nichole Broderick

Assistant Professor

PhD, University of Wisconsin-Madison

138 Levi
nbroder1@jhu.edu
Curriculum Vitae
Group/Lab Website
Google Scholar Profile

Nichole is an Assistant Professor in the Department of Biology. Prior to arriving at JHU, Nichole was an Assistant Professor in the Department of Molecular and Cell Biology and the Institute for Systems Genomics at the University of Connecticut. From 2013-2015, Nichole was an Associate Research Scientist at the Molecular, Cellular & Developmental Biology Department at Yale University. Nichole received her PhD from the University of Wisconsin-Madison with Ken Raffa (Entomology) and Jo Handelsman (Microbiology) and did her postdoctoral research in the lab of Bruno Lemaitre at the EPFL in Lausanne, Switzerland. Her research has focused on characterization of the gut microbiota of insect hosts and study of their impacts on host physiology and susceptibility to disease.

 

The goal of the Broderick Laboratory is to address fundamental questions related to animal biology by understanding the mechanisms that underlie animal-microbiome interactions. We use Drosophila melanogaster and its associated microbiota to study the impacts of beneficial and pathogenic bacteria on host development, physiology, and health using a variety of molecular, genetic, and genomic approaches.

Animals are in constant association with diverse and abundant microbial communities, collectively referred to as the microbiome. These interactions have important roles in animal development and physiology. Research in our lab seeks to address questions such as: How does the microbiome establish and maintain itself? What are the host and microbiota factors that mediate their interactions? How stable are these microbiome-dependent effects in response to perturbation by pathogens and time? Understanding the molecular basis of these interactions will inform our understanding of the evolution of host-microbe associations and define mechanisms that promote animal health.

Link to additional research details. https://brodericklab.com/research.php

2020

  • Lesperance DNA, Broderick NA. Meta-analysis of Diets Used in Microbiome Research and Introduction of the Dietary Composition Calculator (DDCC). G3 (Bethesda) 2020;
    PMID: 32371452
  • Lesperance DN, Broderick NA. Microbiomes as modulators of Drosophila melanogaster homeostasis and disease. Curr Opin Insect Sci 2020; 39:84-90
    PMID: 32339931

2019

2018

2017

2016

2015

2014

2013

2012

  • Broderick NA, Lemaitre B. Gut-associated microbes of Drosophila melanogaster. Gut Microbes 2012; 3(4):307-21
    PMID: 22572876

2010

2009

2006

  • Broderick NA, Raffa KF, Handelsman J. Midgut bacteria required for Bacillus thuringiensis insecticidal activity. Proc. Natl. Acad. Sci. U.S.A. 2006; 103(41):15196-9
    PMID: 17005725 

2005

  • Lucas D, Broderick N, Lehrer R, Bohanan R. Making the grounds of scientific inquiry visible in the classroom. Science Scope 2005; 29(3):39-42

2004

2003

  • Broderick NA, Goodman RM, Handelsman J, Raffa KF. Effect of host diet and insect source on synergy of gypsy moth (Lepidoptera: Lymantriidae) mortality to Bacillus thuringiensis subsp. kurstaki by zwittermicin A. Environ Entomol 2003; 32(2):387-391 

2000

  • Broderick NA, Goodman RM, Raffa KF, Handelsman J. Synergy between zwittermicin A and Bacillus thuringiensis subsp. kurstaki against gypsy moth (Lepidoptera: Lymantriidae). Environ Entomol 2000; 29(1):101-107
    DOI: 10.1603/0046-225X-29.1.101 

Graduate Students

Alexander Barron

Madison Condon

Taylar Mouton

Benjamin Soto

Rose Dziedzic

Danielle Lesperance

Staff

Marika David